论文部分内容阅读
目的探讨结核性胸腔积液诊断中结核感染T细胞斑点实验(T-SPOT.TB)的敏感性和特异性。方法选取2015年3月至2016年3月不明原因胸腔积液患者116例,对其外周血和胸腔积液行T-SPOT.TB检测。比较结核性和非结核性胸腔积液患者阳性结果,分析T-SPOT.TB检测的敏感性和特异性。结果 116例患者中确诊结核性胸膜炎72例,非结核性胸腔积液44例。胸腔积液T-SPOT.TB诊断结核性胸膜炎的敏感性(94.4%)、特异性(95.4%)均明显高于外周血(83.3%、88.9%),且胸腔积液的阳性似然比高于外周血,阴性似然比低于外周血,差异均有统计学意义(P<0.05)。结论以胸腔积液为标本,采用T-SPOT.TB检测结核性胸腔积液的敏感性和特异性较佳。
Objective To investigate the sensitivity and specificity of T-SPOT.TB in the diagnosis of tuberculous pleural effusion. Methods 116 patients with unexplained pleural effusion between March 2015 and March 2016 were selected for T-SPOT.TB detection of peripheral blood and pleural effusion. To compare the positive results of patients with tuberculous and non-tuberculous pleural effusion, the sensitivity and specificity of the T-SPOT.TB assay were analyzed. Results Among the 116 patients, 72 cases were diagnosed as tuberculous pleurisy and 44 cases were non-tuberculous pleural effusion. Pleural effusion T-SPOT.TB diagnosis of tuberculous pleurisy sensitivity (94.4%), specificity (95.4%) were significantly higher than that of peripheral blood (83.3%, 88.9%), and the positive likelihood ratio of pleural effusion In peripheral blood, the negative likelihood ratio was lower than that in peripheral blood, the difference was statistically significant (P <0.05). Conclusion The pleural effusion as a specimen, the detection of tuberculous pleural effusion with T-SPOT.TB sensitivity and specificity better.