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目的探讨丝氨酸/苏氨酸激酶15(STK15)与信号转导转录激活因子3(STAT3)在胃癌中的表达及意义并进行二者相关性分析。方法纳入该院2015年1月—2016年1月确诊为胃癌的患者52例,应用免疫组织化学染色的方法检测STK15和STAT3在胃癌及正常胃黏膜组织中的表达,检测STK15和STAT3表达与胃癌临床病理参数的关系,并分析二者的相关性。结果胃癌组织中STK15与STAT3表达阳性表达率均高于正常胃黏膜组织,差异有统计学意义(P<0.01);胃癌组织中二者的阳性表达与淋巴结转移、TNM分期、分化程度有关(P<0.05);STK15与STAT3在胃癌中的表达呈正相关(r=0.473,P<0.05)。结论 STK15和STAT3在胃癌发生发展中起可能发挥作用,为胃癌的预后评估提供理论依据。
Objective To investigate the expression and significance of serine / threonine kinase 15 (STK15) and signal transducer and activator of transcription 3 (STAT3) in gastric cancer and their relationship analysis. Methods Fifty-two patients diagnosed as gastric cancer from January 2015 to January 2016 were included in the study. The expression of STK15 and STAT3 in gastric cancer and normal gastric mucosa were detected by immunohistochemical staining. The expressions of STK15 and STAT3 in gastric cancer Clinicopathological parameters of the relationship and analysis of the correlation between the two. Results The positive rates of STK15 and STAT3 in gastric cancer tissues were significantly higher than those in normal gastric mucosa (P <0.01). The positive rates of both STK15 and STAT3 in gastric cancer were related to lymph node metastasis, TNM stage and differentiation (P <0.05). There was a positive correlation between the expression of STK15 and STAT3 in gastric cancer (r = 0.473, P <0.05). Conclusion STK15 and STAT3 may play a role in the development of gastric cancer and provide a theoretical basis for the prognosis evaluation of gastric cancer.