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目的 :检测胃癌患者术前、术后血清IL - 10浓度并探讨其意义。方法 :用ELISA检测法测定了 36例胃癌患者术前、术后血清IL - 10浓度 ,以 30例健康人为对照。结果 :胃癌患者术前、术后血清IL - 10浓度均高于健康人 ,术前血清IL - 10浓度高于术后 ,低分化胃癌患者血清IL - 10浓度高于中、高分化者 (P <0 .0 1)。结论 :胃癌细胞可能产生IL - 10 ,并藉此逃避机体的免疫监视。IL - 10可能是一个可反映胃癌分化程度、估计预后的指标
Objective: To detect the concentration of serum IL - 10 in patients with gastric cancer before and after surgery and to explore its significance. Methods: The serum levels of IL - 10 in 36 patients with gastric cancer before and after operation were measured by ELISA, and 30 healthy controls were used as controls. Results: The serum IL - 10 levels in patients with gastric cancer before and after operation were significantly higher than those in healthy controls. The preoperative serum IL - 10 levels were higher than those in patients with poorly differentiated gastric cancer. <0 .0 1). Conclusion: Gastric cancer cells may produce IL - 10, and thus escape the body ’s immune surveillance. IL - 10 may be an indicator of gastric cancer differentiation and prognosis