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目的:调查分析我市2007-2008年238株尿路感染病原菌的构成比及耐药性,为合理使用抗生素提供科学依据。方法:采用常规方法对尿路感染病原菌进行鉴定,用KB法进行药物敏感试验。结果:革兰阴性杆菌占73.9%(176/238);革兰阳性球菌占21.4%(51/238);真菌占4.6%(11/238)。病原菌中,大肠埃希菌分离率最高,占62.2%(148/238)。药敏分析表明:尿路感染病原菌对多种常用抗菌药物均产生了不同程度的耐药性,仅万古霉素对革兰阳性球菌、亚胺培南对革兰阴性杆菌保持了100%的抗菌活性。产超广谱β-内酰胺酶(ES-BLs)细菌总检出率为41.3%(69/167)。结论:尿路感染必须依据病原学检查和药敏试验的结果进行治疗,才能提高临床治愈率。
Objective: To investigate and analyze the composition ratio and drug resistance of 238 strains of urinary tract infection pathogens from 2007 to 2008 in our city, and provide a scientific basis for rational use of antibiotics. Methods: The routine method was used to identify the pathogen of urinary tract infection, and KB method was used for drug sensitivity test. Results: Gram-negative bacilli accounted for 73.9% (176/238); Gram-positive cocci accounted for 21.4% (51/238); fungi accounted for 4.6% (11/238). Pathogenic bacteria, Escherichia coli separation rate was the highest, accounting for 62.2% (148/238). Drug susceptibility analysis showed that: urinary tract pathogens on a variety of commonly used antimicrobial drugs have varying degrees of resistance, only vancomycin against Gram-positive cocci, imipenem against gram-negative bacilli maintained 100% antibacterial active. The total detection rate of ES-BLs was 41.3% (69/167). Conclusion: Urinary tract infection must be based on the results of etiological examination and susceptibility testing to improve the clinical cure rate.