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雌激素用于治疗更年期妇女某些生殖器官或非生殖器官疾病已有多年。用雌激素治疗非生殖器官疾病,如血管运动障碍,用量较大,可引起子宫内膜增生。有时更年期妇女存在情绪压抑或性淡漠则需加服雄激素。如用雌激素治疗时不伴用对抗剂,则可对子宫内膜和乳腺产生不良影响。为减少这种不良影响,可规则、间断地应用孕激素。但用孕激素后可发生撤退性子宫出血,从而令绝经后妇女不乐于接受。单用较大剂量孕激素治疗血管运动障碍亦能奏效,但可引起性交痛并容易发生阴道炎。采用固醇类激素治疗血管运动障碍的效果看来与对下丘脑-垂体轴的稳定作用有关。为寻求理想的药物,经研究合成了OrgOD14(17羟-7甲基-5烯-20炔-19去甲孕酮)。实验动物应用OrgOD14后发现该药同时具有
Estrogen has been used for many years in the treatment of certain genital or non-genital diseases in menopausal women. Estrogen treatment of non-genital diseases, such as vascular dyskinesia, a larger amount, can cause endometrial hyperplasia. Menopausal women and sometimes emotional depression or apathetic need to add service androgen. If not treated with estrogen antagonist, you can endometrial and breast adverse effects. To reduce this adverse effect, regular, intermittent use of progesterone. However, progesterone can occur after withdrawal of uterine bleeding, so that postmenopausal women are not willing to accept. Single larger progesterone treatment of vascular dyskinesia can also work, but can cause painful sexual intercourse and prone to vaginitis. The effect of steroid hormones on vasomotor disorders appears to be related to the stabilizing effect on the hypothalamus-pituitary axis. In order to find the ideal drug, OrgOD14 (17-hydroxy-7-methyl-5-en-19-nor-progesterone) was synthesized. The experimental animals using OrgOD14 found that the drug has both