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作者采用四甲基谷氮唑盐（ＭＴＴ）实验检测全反式维甲酸（ＡＴＲＡ）对人胰腺癌细胞系ＪＦ－３０５细胞的生长抑制作用；通过细胞病理学和电镜观察经ＡＴＲＡ作用后人胰腺癌细胞形态、超微结构的改变。结果提示：ＡＴＲＡ能够明显地抑制人胰腺癌细胞生长（Ｐ＜０．０５），随药物浓度增加而抑制作用增强，最大抑制率达３４．７％。经ＡＴＲＡ处理后增殖细胞明显减少（Ｐ＜０．０１），细胞内代谢减慢，细胞的分泌功能恢复，细胞恶性程度降低。作者认为：ＡＴＲＡ可抑制人胰腺癌细胞系ＪＦ－３０５细胞的生长并诱导其成熟分化。
The authors measured the growth inhibitory effect of all-trans retinoic acid (ATRA) on human pancreatic cancer cell line JF-305 by using tetramethyl glutamate (MTT) assay; observed human pancreas after ATRA treatment by cytopathology and electron microscopy. Changes in the morphology and ultrastructure of cancer cells. The results suggest that: ATRA can significantly inhibit the growth of human pancreatic cancer cells (P <0.05), with the increase in drug concentration and inhibition of enhanced, the maximum inhibition rate of 34.7%. ATRA treatment significantly reduced the proliferation of cells (P <0.01), intracellular metabolism slowed down, the cell’s secretory function restored, the degree of cell malignancy decreased. The authors believe that: ATRA can inhibit the growth of human pancreatic cancer cell line JF-305 and induce its maturation and differentiation.