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目的观察不同剂量的弗氏完全佐剂对类风湿关节炎(Rheumatoid arthritis,RA)模型复制的影响,探讨RA模型复制中弗氏完全佐剂的最佳注射量,以期为RA的实验研究提供较好的模型复制方法。方法采用“病证结合”复合佐剂性关节炎模型复制方法,即“风、寒、湿”环境因素+弗氏完全佐剂的模型复制方法,观察不同注射量的弗氏完全佐剂对RA模型复制的影响。结果 0.1mL模型复制组有自愈的趋势;0.15mL模型复制组大鼠体质量、跖围改变呈进行性下降趋势,X线可见骨质破坏情况较贴近临床患者骨质的改变;0.2mL模型复制组骨质呈粉碎性破坏。结论 0.15mL注射量可能是RA模型复制中的最佳注射量。
Objective To observe the effects of different doses of Freund’s complete adjuvant on the replication of rheumatoid arthritis (RA) model and to explore the optimal injection of Freund’s complete adjuvant in RA model replication in order to provide better experimental results for RA Good model copy method. Methods The method of replication of the compound adjuvant arthritis model was used to replicate the model of “adjuvant arthritis with wind, cold and wetness” and complete Freund’s adjuvant to observe the effect of Freund’s complete Effect of Adjuvant on RA Model Replication. The results showed that 0.1mL model group had self-healing tendency. Body mass and plantar circumference of 0.15mL model group decreased progressively. X-ray showed that bone destruction was more close to that of clinical patients. 0.2mL model Replication group bone was comminuted destruction. Conclusion 0.15mL injection volume may be the best injection in RA model replication.