论文部分内容阅读
通过树鼩与大鼠的比较试验,表明树鼩对戊巴比妥钠、速尿、肝炎灵和敌百虫产生与大鼠相似的药理效应,但其效应强度不同.树鼩对药物的敏感性比大鼠低,连续多次ip戊巴比妥钠使树鼩产生睡眠、麻醉和呼吸频率降低一半所需的剂量以及单次ip速尿产生50％最大利尿效应所需的剂量平均为大鼠产生相同强度效应的1.53倍.树鼩对药物的耐受能力也较强,其戊巴比妥钠LD100、敌百虫LD50和肝炎灵LD50平均为大鼠致死量的1.98倍.此外,树鼩也明显加速SD-Na的消除速度,其消除速率常数为大鼠的1.46倍。我们认为,树鼩较为合适的给药剂量约为大鼠剂量的1.53倍,可根据药理效应作适当的调整。
Comparison of the tree shrews and rats showed that tree shrews produced similar pharmacological effects on sodium pentobarbital, furosemide, hepatitis and trichlorfon but had different effects on the strength of the tree shrews Sex Lower than in rats, ip consecutive doses of sodium pentobarbital to sleep in the tree shrew, the dose required to reduce anesthesia and respiratory rate in half, and the dose required to produce a 50% maximal diuretic effect in a single ip furosemide were on average large Rats produced 1.53 times the same intensity effect.Studies on drug tolerance is also strong, the pentobarbital sodium LD100, trichlorfon LD50 and hepatitis Ling LD50 average lethality in rats 1.98 times.In addition, the tree鼩 also significantly accelerated the elimination rate of SD-Na, the elimination rate constant of 1.46 times that of rats. In our opinion, the appropriate dosage of tree shrew is about 1.53 times of that of the rat, which can be adjusted according to the pharmacological effect.