目的通过150例先兆早产病例分析,研究胎儿纤维连接蛋白(fFN)和测量宫颈长度联合预测早产的价值。方法对2011年5月至2012年5月在包钢三医院产科门诊急诊诊断为先兆早产需住院保胎治疗的孕妇150例,测定其阴道分泌物中fFN及部分病例超声测量子宫颈长度,追踪病例结果进行分析。结果 150例病例中,37例fFN阳性,阳性率为24.67%,37例fFN检测呈阳性者在7、14d和37周内分娩,分娩率分别为18.92%,37.83%,46.65%;阴性者则分别为0%,0%,3.57%。对于7、14d和37周内分娩的阴性预测值分别为100.0%、100.0%和96.46%。同时98例孕妇进行了宫颈长度的测量,22例孕妇的宫颈长度≤26mm,其18例在7d,14d,37周内分娩,其分娩率为22.72%,40.91%,81.82%。二者同时异常预测先兆早产孕妇发生早产的敏感性为76.47%、特异性为81.70%、阳性预测值为92.30%、阴性预测值为94.37%。结论 (1)fFN呈阳性对预测早产有一定价值,宫颈长度超声测量也是一种有价值的早产预测手段;(2)宫颈长度测量与fFN检测两者结合可提高早产预测的准确性。 Objective To evaluate the value of fetal fibronectin (fFN) and measuring the length of the cervix in predicting preterm labor by analyzing 150 cases of threatened premature labor. Methods From May 2011 to May 2012, 150 pregnant women with obstetric and prenatal diagnosis of threatened preterm labor in obstetric and gynecological emergency department of Baosteel Third Hospital were enrolled. The fFN in vaginal secretions and some patients’ Case results were analyzed. Results Among the 150 cases, 37 cases were positive for fFN, the positive rate was 24.67%. The positive rate of fFN was 37.4%, 37.6% in 37 cases and 37.6% Respectively 0%, 0%, 3.57%. The negative predictions for childbirth within 7, 14 and 37 weeks were 100.0%, 100.0% and 96.46%, respectively. At the same time, 98 cases of pregnant women were measured the length of the cervix, 22 cases of pregnant women with cervical length ≤ 26mm, and 18 cases delivered within 7d, 14d and 37d. The delivery rate was 22.72%, 40.91% and 81.82% respectively. The sensitivity of both preterm and preterm birth women with preterm birth abnormalities was 76.47%, specificity was 81.70%, positive predictive value was 92.30%, negative predictive value was 94.37%. Conclusions (1) Positive fFN has some value in predicting preterm birth. Cervical length ultrasound is also a valuable means of predicting preterm birth. (2) The combination of cervical length measurement and fFN test can improve the accuracy of preterm birth prediction.