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CD2 8 -B7是T细胞活化所必需的共刺激信号。在SLE患者中存在着CD2 8-B7共刺激信号尤其是APC上的B7(主要是B7- 2 )的表达异常 ,这些异常可能导致SLE患者T细胞增殖异常及细胞因子分泌格局异常等
CD2 8 -B7 is a costimulatory signal necessary for T cell activation. In patients with SLE, there is abnormal expression of CD2 8-B7 costimulatory signal, especially B7 (mainly B7-2) on APC. These abnormalities may lead to abnormal T cell proliferation and abnormal cytokine secretion in patients with SLE