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目的研究癌基因ERBB3编码的ERBB3蛋白在胃癌组织和正常组织的表达情况,探讨ERBB3基因在胃癌发生发展中的作用。方法65例不同病理类型的胃癌组织(Lauren病理分类,其中肠型胃癌43例,弥散型胃癌22例)及65例正常对照组织进行免疫组织化学染色,并按照胃癌的不同病理类型、TNM分期将检测结果进行对比观察。结果胃癌组(65例)ERBB3蛋白过表达者7例,占10.8%,而正常对照组(65例)只有1例过表达,占1.6%,两组相比差异有显著性(P<0.01),且ERBB3蛋白在弥散型胃癌的过表达率高于肠型胃癌(27.3%vs2.3%,P<0.01)。ERBB3蛋白过表达与胃癌TNM分期相关联,Ⅳ期患者中ERBB3过表达的阳性率显著高于其他期的患者。结论ERBB3蛋白在胃癌中存在过表达,提示患者预后不良,其机制可能与其参与了胃癌的低分化病理过程有关。
Objective To investigate the expression of ERBB3 protein in gastric cancer and normal tissues and to explore the role of ERBB3 in the development of gastric cancer. Methods 65 cases of different pathological types of gastric cancer (Lauren pathological classification, including 43 cases of intestinal type of gastric cancer, 22 cases of diffuse gastric cancer) and 65 cases of normal control tissue immunohistochemical staining, and in accordance with the different pathological types of gastric cancer, TNM staging Test results were compared. Results There were 7 cases (10.8%) of ERBB3 overexpression in gastric cancer group (65 cases), and only 1 case (65%) in normal gastric cancer group (1.6%), the difference was significant (P <0.01) , And the overexpression rate of ERBB3 protein in diffuse gastric cancer was higher than that in intestinal type gastric cancer (27.3% vs 2.3%, P <0.01). The overexpression of ERBB3 is associated with the TNM staging of gastric cancer, and the positive rate of ERBB3 overexpression in stage IV patients is significantly higher than that in other stages. Conclusion The overexpression of ERBB3 in gastric cancer suggests that the prognosis of patients with ERBB3 may be related to poorly differentiated gastric cancer.