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作者应用双盲及交换试验法对14例每年至少发作8次的非生殖器皮肤单纯疱疹患者口服无环鸟苷预防复发,病人随意分配治疗程序,或口服200mg无环鸟苷或安慰剂,4次/d(A治疗期),然后再交换到第二期(B治疗期),每个治疗期持续至多12周。如病人在A治疗期出现复发或在完成A治疗期后,则开始B治疗期。结果:14例病人中,11例完成了治疗,其中男2例,女9例,平均年龄33.9岁(21～60),试验前每年复发HSV的平均数目为12.5(8～20),一般病程平均8.8天(4～18),为HSV-1病毒8例,HSV-2型3例。复发部位:嘴唇2例,嘴唇并有其他部位(耳、颊、鼻、指或大腿)者7例仅限于指部者2例。
The authors applied double-blind and crossover trials to 14 patients with non-genital herpes simplex skin at least 8 episodes each year to prevent the recurrence of oral acyclovir. Patients were randomized to either a treatment regimen or oral administration of 200 mg acyclovir or placebo, 4 times / d (A treatment period) and then to the second phase (B treatment period), each treatment period up to 12 weeks. If the patient relapsed during treatment A or after treatment A was completed, treatment B started. Results: Of the 14 patients, 11 completed the treatment, including 2 males and 9 females, with an average age of 33.9 years (21-60). The average number of recurrent HSVs before the trial was 12.5 (8-20) An average of 8.8 days (4 ~ 18), HSV-1 virus in 8 cases, 3 cases of HSV-2 type. Recurrence sites: 2 cases of lips, lips and other parts (ears, buccal, nasal, fingers or thighs) 7 cases were limited to the fingers in 2 cases.