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为了选择环磷酰胺(CTX)适当的时间间隔冲击治疗重症系统性红斑狼疮(SLE),更好地观察其疗效和副反应。将40例重症SLE患者随机分为A、B两组,分别给予每1—2周和3—4周环磷酰胺冲击治疗(IV—CTX)一次,每次1g,同时口服强的松。结果A组临床疗效快,尿蛋白显著下降(P<0.01),抗dsDNA滴度显著下降(P<0.01),血清C3、CH50显著上升(P<0.01),两组间副反应无显著性差异(P>0.05)。结果提示A组疗效明显优于B组。
In order to select cyclophosphamide (CTX) at the appropriate time interval impact treatment of severe systemic lupus erythematosus (SLE), to better observe its efficacy and side effects. Forty patients with severe SLE were randomly divided into A and B groups. The patients were treated with cyclophosphamide (IV-CTX) once or twice a week for 1 to 2 weeks and prednisone for 1 g each. Results The clinical curative effect of group A was rapid, the proteinuria of urine decreased significantly (P <0.01), the titer of anti-dsDNA decreased significantly (P <0.01) and the level of serum C3 and CH50 increased significantly (P <0.01). There was no significant difference between the two groups (P> 0.05). The results suggest that the efficacy of group A is better than that of group B.