论文部分内容阅读
目的:研究环维黄杨星D基质型贴剂的体外释药机制。方法:分别制备环维黄杨星D单层和双层贴剂,采用体外释放度法和体外经皮渗透法研究其体外释药机制。结果:单层贴剂以一级方程拟合较优,其释药速率随药物量减少而降低;双层贴剂以Higuchi方程拟合较优,属于骨架型释药系统。两种贴剂的体外经皮渗透均以零级动力学方程拟合为优,符合Fick扩散定律。结论:贴剂的结构能改变药物的释药模式,双层贴剂中药物储库层的参与释放,能够获得平稳的释药曲线和稳定的透皮速率。
Objective: To study the in vitro drug release mechanism of cyclovirobuxine D matrix patch. METHODS: Cyclovirobuxine D monolayer and double-layer patch preparations were prepared respectively. The in vitro release mechanism and in vitro percutaneous permeation method were used to study the in vitro drug release mechanism. RESULTS: The single-layer patch was better fitted by the first-order equation, the drug release rate decreased with the decrease of the drug amount, and the double-layer patch was better fitted by the Higuchi equation, belonging to the skeleton-type drug delivery system. The transdermal permeation of the two patches in vitro was well-adjusted by a zero-order kinetic equation, which was in accordance with Fick’s law of diffusion. Conclusion: The structure of the patch can change the mode of drug release, and the release of the drug reservoir layer in the double-layer patch can achieve a stable drug release profile and a stable transdermal rate.