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采用反相高效液相色谱法检测二氢奎尼丁血药浓度。二氢奎尼丁最低检测量为10ng/ml,血浆最低检测度为50ng/ml。标准曲线回归方程Y=0.9638X—0.003,相关系数r=0.9982,日内、日间变异度<5.7%。8名健康志愿者口服单剂量serecor 300mg药代动力学研究表明,均符合一室开放模型,且一室、二室间差异不显著。C_(max):0.4637±0.13μg/ml,T_(max):7.72±2.53h,t_(1/2)ka:2.6193±0.96h,t_(1/2)ke:15.4043±10.56h,AUC:12.9646±2.08(μg/ml)·h。
Dihydroquinidine plasma concentrations were determined by reversed-phase high performance liquid chromatography. Dihydroquinidine test the lowest amount of 10ng / ml, the lowest plasma test 50ng / ml. The standard curve regression equation Y = 0.9638X-0.003, correlation coefficient r = 0.9982, intra-day and inter-day variation <5.7%. Eight healthy volunteers oral single-dose serecor 300mg pharmacokinetic studies have shown that they are in line with the open-studio model, and one room, two rooms was no significant difference. Cmax: 0.4637 ± 0.13 μg / ml, T max: 7.72 ± 2.53 h, t 1/2: ka: 2.6193 ± 0.96 h, t 1/2 ke: 15.4043 ± 10.56 h, AUC: 12.9646 ± 2.08 (μg / ml) · h.