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目的:寻找合成红霉胺衍生物的简便方法。方法:以红霉素A和相应的胺在微波辐射条件下,利用Leuckart反应一步合成目标化合物。结果:合成了6个红霉胺衍生物,其结构均经IR、ESI-MS及13C-NMR确证。结论:微波辐射催化下一步合成红霉胺衍生物,方法简单、有效。
Objective: To find a convenient method for synthesizing erythromycylamine derivatives. Methods: Erythromycin A and its corresponding amine under microwave irradiation conditions, the use of Leuckart reaction step synthesis of the target compound. Results: Six erythromycylamine derivatives were synthesized and their structures were confirmed by IR, ESI-MS and 13C-NMR. Conclusion: The synthesis of erythromycylamine derivatives by microwave irradiation is simple and effective.