本实验采用不同量华支睾吸虫囊蚴一次过感染家兔43只,然后分期剖杀。以肝内寄生成虫数目分为100条以下低虫、100～200条高虫两组。从感染到剖杀时分为三个月短期及六个月长期两组。肝脏组织学观察结果; 1 华支睾吸虫感染后,早期肝硬化20只,发生率46.5％,纤维化16只、37.2％,未见纤维组织增生7只、16.3％、肝硬化伴细菌感染占80 ％。全部家兔均有慢性胆管炎,其中肝内胆管乳头状瘤15只。 2 肝内成虫数目与肝硬化关系,两组肝硬化发生率无统计学意义(P>0.05)。 3 感染时间与肝硬化关系,两组肝硬 In this experiment, different doses of Clonorchis sinensis metacercariae infected 43 rabbits at one time, and then staged. The number of parasitic adults within the liver is divided into 100 following low insects, 100 to 200 high insects two groups. Divided into three months short-term and long-term six months from infection to the time of the killing. The results of histological examination of liver showed that there were 20 early cirrhosis and 46.5% of early cirrhosis, 16 of fibrosis and 37.2% of fibrosis, 7 of fibrosis, 16.3% of cirrhosis and bacterial infection 80%. All rabbits had chronic cholangitis, including 15 intrahepatic bile duct papillomas. The relationship between the number of liver and cirrhosis, liver cirrhosis incidence in both groups was not statistically significant (P> 0.05). 3 infection time and cirrhosis, two groups of liver cirrhosis