论文部分内容阅读
目的:比较间羟胺与去甲肾上腺素对老年脓毒性休克患者的临床疗效。方法:在这个多中心前瞻性队列研究中，老年脓毒性休克患者分为间羟胺组（n n=100）及去甲肾上腺素组（n n=100）；观察28 d生存情况及平均住院天数、血流动力学指标及肾脏功能。n 结果:间羟胺组平均住院天数低于去甲肾上腺素组（n P0.05）；用升压药第3和7天间羟胺组平均尿量高于去甲肾上腺素组（均n P<0.05），用升压药第3、7和14天间羟胺组尿素氮低于去甲肾上腺素组（均n P<0.05），用升压药第7和14天间羟胺组肌酐和血液净化治疗率均低于去甲肾上腺素组（n P<0.05）。n 结论:间羟胺在改善老年脓毒性休克患者的28d生存率及血流动力学的作用与去甲肾上腺素相近，但在降低平均住院天数、肾功能保护方面优于去甲肾上腺素。“,”Objective:To compare the effect of metaraminol and norepinephrine (NA) on elderly patients with septic shock.Methods:In this multicenter prospective cohort study elderly patients with septic shock were divided into the metaraminol group (n n=100) and NA group (n n=100). The 28-day survival and average hospital stay, the hemodynamics and renal function of the patients were observed.n Results:The average hospital stay in the metaraminol group was lower than that in the NA group (n P 0.05). The average urine output at day 3 and 7 after the administration of vasopressor in the metaraminol group were higher than those in the NA group (all n P< 0.05), blood urea nitrogen at day 3, 7 and 14 after the administration of vasopressor in the metaraminol group were lower than those in the NA group (all n P < 0.05), and the creatinine at day 3, 7 and 14 after the administration of vasopressor and the rate of renal replacement therapy in the metaraminol group were lower than those in the NA group (all n P < 0.05).n Conclusions:Metaraminol has similar effect to norepinephrine in improving 28-day survival and hemodynamics of elderly patients with septic shock, but is superior to norepinephrine in reducing the average hospital stay and protecting renal function.