用约氏疟原虫（Ｐ．ｙ）裂殖子抗原免疫ＥＡＬＢ／ｃ小鼠，再用约氏疟原虫非致死株１０５ＰＲＢＣ／只攻击。免疫组小鼠血中原虫推迟出现，提早消失，原虫率明显低于未免疫小鼠和佐剂对照小鼠；佐剂对照组仅原虫高峰推迟出现，与易感小鼠无明显差异。抗原免疫小鼠脾脏Ｔ淋巴细胞对抗原特异性和非特异性增殖反应明显高于其它两组，原虫攻击后增殖反应普遍受到抑制，但免疫小鼠比其它两组恢复快，感染后１８天即恢复至正常水平。 EALB / c mice were immunized with P. yohii merozoite antigen and challenged with 105PRBC / non-lethal strain of Plasmodium yoelii. In the immunized group, the protozoa in the blood were postponed and disappeared prematurely, the protozoal rate was significantly lower than that in the non-immunized mice and the adjuvant-treated mice. In the adjuvant control group, only the protozoa peak was delayed, showing no significant difference from the susceptible mice. The antigen-specific and nonspecific proliferative responses of splenic T lymphocytes to antigen in mice were significantly higher than those in the other two groups. Proliferation responses were generally inhibited after challenge with protozoal, but immunized mice recovered faster than the other two groups and resumed 18 days after infection To normal level.