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用体重200～250g的Wister雄鼠,在苯巴比妥麻醉下,在进食和空腹情况下,以大剂量苯乙双胍(降糖灵PEBG500mg/kg)和二甲双胍(降糖片DMBG3g/kg),溶于水口服,然后测定血糖、乳酸、胰岛素和升血糖素。每30分钟抽血1次,共4小时。仅空腹服双胍鼠在服后3小时血糖明显下降(30mg/dl)。用双胍治疗的鼠,血乳酸值增加。于饲食的小鼠中,仅服PEBG鼠见血浆升血糖素明显增加。空腹动物服降糖灵和降糖片后,其升血糖素明显增加,与严重低血糖发展相平行。所有治疗鼠,在整个试验中,放射反应胰岛素值持续减低,尤以空腹鼠表现曼著。结论:①双胍类药物的毒性作用,决定于动物的
Wister male rats weighing 200-250g were treated with phenobarbital (hypoglycemic PEBG 500mg / kg) and metformin (hypoglycemic tablets DMBG3g / kg) under phenobarbital anesthesia in fasting and fasting conditions, dissolved in Water orally, and then measured blood sugar, lactate, insulin and glucagon. Blood is drawn every 30 minutes for 4 hours. Only fasting biguanide rats 3 hours after serving significantly decreased blood glucose (30mg / dl). With biguanide-treated mice, blood lactate increased. In feeding mice, only serving PEBG mice showed a significant increase in plasma glucagon. Fasting animal hypoglycemic and hypoglycemic tablets, the glucagon significantly increased, parallel with the development of severe hypoglycemia. All treated mice, in the entire experiment, the value of radioactive insulin continued to decrease, especially in fasting mice Mann. Conclusions: ① The toxicity of biguanides depends on the animals