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人们早已认识,胃粘膜具有保护自身不被胃酸消化的功能,其机理为胃粘膜存在一个屏障有关。现代教科书记载,胃粘膜屏障由胃粘膜细胞屏障和胃粘液屏障组成。前者主要由胃粘膜上皮细胞顶部细胞膜及细胞之间致密的脂蛋白层所构成,可阻止氢离子向粘膜细胞内移动;后者因粘液不断分泌,可降低酸度,亦阻止粘膜被胃酸消化。然而,近年来,对粘膜屏障概念有新的认识。Moody等认为,许多类型的胃粘膜损害并非都是粘膜层增加对氢离子的渗透性这一机理所致,而胃粘液含95％
It has long been known that gastric mucosa has the function of protecting itself from gastric acid digestion and its mechanism is related to the presence of a barrier in gastric mucosa. Modern textbooks have documented that the gastric mucosal barrier consists of a gastric mucosal cell barrier and a gastric mucus barrier. The former mainly by the top of the gastric mucosa epithelial cells and dense between the cell membrane lipoprotein composition, to prevent hydrogen ions to move within the mucosal cells; the latter due to mucus continued secretion, can reduce the acidity, but also prevent mucosal gastric acid digestion. However, in recent years, there has been a new understanding of the concept of mucosal barrier. Moody and others argue that many types of gastric mucosal damage are not caused by the mechanism by which the mucosa increases permeability to hydrogen ions, whereas gastric mucus contains 95%