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目的 :探讨根治性肝癌术后近期和远期复发因素 ,以期对高复发倾向人群抗复发提出针对性对策。方法 :回顾分析 1994年 5月~ 1998年 1月 16 2例根治性肝癌切除病例的临床资料 ,以影像学发现肿瘤复发及患者死亡或末次随访日期为截点确定无瘤生存时间 ,将术后复发病人分为近期复发 (≤ 2年 )、远期复发 (>2年 )及未复发 3组 ,确定复发危险因素。结果 :本组术后 1、 3、 5年无瘤生存率分别为 6 7. 1、 4 4 . 7及 2 5 . 5 %。与肿瘤近期复发相关因素为发现方式、肿瘤大小、血管癌栓、INM分期 ;与后期复发相关因素为有无肝硬化及其类型、肝功Child -Pugh分级和有无子瘤。结论 :根治性肝癌切除术后近期和远期复发的临床病理因素不同 ,及早发现小肝癌是预防近期复发的关键 ,兼顾术前肝功能可以对远期复发有预测作用
Objective: To investigate the short-term and long-term recurrence factors of radical liver cancer after operation, and to put forward countermeasures for anti-recurrence of high recurrence tendency group. Methods: The clinical data of 162 cases of radical liver cancer resection from May 1994 to January 1998 were retrospectively analyzed. The tumor-free survival time was determined by imaging findings of tumor recurrence and patient’s death or the last follow-up date as interception point. The postoperative Recurrence patients were divided into the recent recurrence (≤ 2 years), long-term recurrence (> 2 years) and no recurrence of 3 groups to determine the risk of relapse. Results: The 1, 3, 5-year disease-free survival rates of this group were 67.1, 44.7 and 25.5% respectively. And the recent relapse of tumor-related factors for the detection of tumor size, tumor thrombosis, INM staging; and recurrence-related factors for the presence or absence of cirrhosis and its type, liver function Child-Pugh classification and the presence or absence of sonoma. Conclusions: The clinical and pathological factors of short-term and long-term recurrence of radical liver cancer resection are different. Early detection of small hepatocellular carcinoma is the key to prevent the recent recurrence. Considering the preoperative liver function can predict the long-term recurrence