接受抗逆转录病毒药物(ARV)治疗的艾滋病患者潜在发生药物相互作用(DDIs)的高风险,而其药物相互作用的显著特点是不易辨识、不可避免、难以控制,且会对治疗产生显著影响,并给医药保健系统增加潜在的机会性成本。DDIs无论在发达国家还是资源匮乏的地方都普遍存在,而且,后者存在的潜在成本可能更大。虽然DDIs在艾滋病治疗中无法避免,但很多时候仍然可以得到较好的控制,以减轻其对患者造成的危险和带来的财力负担。发达国家上市的新药和二线药物较多,使得抗逆转录病毒疗法和联合用药的可选择范围更大,故对DDIs的监控范围也更广。电子处方和患者用药电子记录的问世为DDIs的鉴别和监管提供了方便。针对HIV药物相互作用的电子检索数据库是一种非常实用的工具,能有效帮助HIV专科医生和非专科医生应对抗逆转录病毒药物引发的DDIs。目前虽然存在能警告处方医师有关DDIs的普通查询系统,但仍有迹象表明,在改善处方质量、安全配制风险药物、谨慎采用HIV治疗的复杂治疗方案的基础上,有必要建立专业人员查询数据库,并将电子处方或电子配药系统纳入其中。 HIV patients receiving ARV treatment are at a high risk of potential drug interactions (DDIs), and their drug interactions are notably characterized as unreadable, unavoidable, difficult to control, and have a significant impact on treatment , And add potential opportunity costs to the healthcare system. DDIs are ubiquitous both in developed countries and in resource-poor places, and the latter may have greater potential costs. Although DDIs are unavoidable in the treatment of AIDS, they often remain well controlled to reduce their risk to patients and the financial burden. Developed countries listed more new drugs and second-line drugs, making the antiretroviral therapy and combination of drugs to choose a larger range, so the monitoring of DDIs broader. The advent of electronic prescriptions and patient medication electronic records has provided convenience for the identification and regulation of DDIs. The electronic searchable database of HIV drug interactions is a very useful tool to help HIV specialists and non-specialists cope with antiretroviral drug-induced DDIs. Although there are currently general inquiry systems that warn the prescribing physicians about DDIs, there are still indications that it is necessary to establish a database of professionals to search for information on the basis of improving the quality of prescriptions, safely formulating at-risk drugs, and adopting cautious HIV treatment of complex treatment plans. And incorporate an electronic prescription or electronic dispensing system.