慢性粒细胞白血病 (CML )是造血干细胞水平的恶性克隆性疾病 ,确诊后经过 1年～ 4年的慢性期后 ,多数患者进入加速期和 /或急变期 ,表现为对羟基脲耐药 ,肝脾进行性肿大 ,血小板持续增高 ,骨髓中原始幼稚细胞增多或出现附加染色体异常等。此时常规治疗方法疗效不佳 ,但大多数患 Chronic myeloid leukemia (CML) is a malignant clonal disease at the level of hematopoietic stem cells. Most patients enter the accelerated phase and / or the blast crisis after one year to 4 years of chronic phase of diagnosis. They are resistant to hydroxyurea, liver Splenomegaly, thrombocytopenia continued to increase bone marrow naive cells increased or additional chromosomal abnormalities. At this point conventional treatment ineffective, but most patients