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目的:探讨薏苡仁甘油三酯注射液在三维适形放疗同步吉西他滨化疗治疗局部晚期胰腺癌中的免疫调节功能及对生存的影响。方法:56例局部晚期的胰腺癌随机分为治疗组和对照组。对照组:吉西他滨同步三维适形放疗;治疗组:薏苡仁甘油三酯注射液(100 ml/d)联合吉西他滨同步三维适形放疗,连用21、28 d为1个周期,共使用2个疗程,分别测定治疗前后CD3、CD4、CD8、CD4/CD8的值。结果:治疗组CD4+、CD4+/CD8+、NK细胞治疗后比治疗前显著提高(P<0.05),治疗组中位生存期17.2个月,对照组12.4个月(P<0.05);结论:薏苡仁甘油三酯注射液能提高接受三维适形放疗同步吉西他滨化疗的局部晚期胰腺癌患者的免疫能力,提高患者中位生存期。
Objective: To investigate the immunomodulatory function of Coix Seed Triacylglycerol Injection in three-dimensional conformal radiotherapy combined with gemcitabine chemotherapy for locally advanced pancreatic cancer and its effect on survival. Methods: 56 cases of locally advanced pancreatic cancer were randomly divided into treatment group and control group. Control group: gemcitabine synchronous three-dimensional conformal radiotherapy; treatment group: Coix Seed Triacylglycerol injection (100 ml / d) combined with gemcitabine synchronous three-dimensional conformal radiotherapy, 21,28 d for 1 cycle, a total of 2 courses, The values of CD3, CD4, CD8, CD4 / CD8 before and after treatment were measured respectively. Results: The CD4 +, CD4 + / CD8 + and NK cells in treatment group were significantly higher than those before treatment (P <0.05), and the median survival time was 17.2 months in treatment group and 12.4 months in control group (P <0.05). Conclusion: Triglyceride injection can improve the immune capacity of patients with locally advanced pancreatic cancer receiving three-dimensional conformal radiotherapy combined with gemcitabine chemotherapy and improve the median survival of patients.