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目的:探讨前列腺素F2α类药物对青光眼患者房水TGF-β2、NO及促红细胞生成素的影响。方法:选取2008-12/2010-01于本院进行治疗的40例青光眼患者为研究对象,将其设为观察组,对其采用前列腺素F2α类药物进行治疗,后选取40名健康人为对照组,分别于治疗前后对青光眼患者和健康人的房水TGF-β2、NO及促红细胞生成素进行检测,同时将患者的治疗效果及不良反应发生率等进行统计及比较。结果:经研究比较发现,治疗前青光眼患者的TGF-β2高于治疗后及对照组(P<0.05),而治疗前青光眼患者NO及红细胞生成素高于治疗后及对照组(P<0.01),均有统计学意义。结论:前列腺素F2α类药物对青光眼患者房水TGF-β2、NO及促红细胞生成素的影响较大,对于患者的治疗效果较好,值得临床推广应用。
Objective: To investigate the effects of prostaglandin F2α on aqueous humor TGF-β2, NO and erythropoietin in patients with glaucoma. Methods: Forty patients with glaucoma treated in our hospital from December 2008 to January 2010 were enrolled in the study. Subjects were treated with prostaglandin F2α, and 40 healthy volunteers were selected as the control group The levels of TGF-β2, NO and erythropoietin in the aqueous humor of patients with glaucoma and healthy people were measured respectively before and after treatment. At the same time, the treatment effect and the incidence of adverse reactions were compared and statistically analyzed. Results: The study found that TGF-β2 in patients with pre-treatment glaucoma was higher than that in the control group (P <0.05), while NO and erythropoietin in patients with pre-treatment glaucoma were significantly higher than those in the control group (P <0.01) , All with statistical significance. CONCLUSION: Prostaglandin F2α has a great effect on aqueous humor TGF-β2, NO and erythropoietin in patients with glaucoma. It has good therapeutic effect on patients and deserves clinical application.