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精子发生是在睾丸内由生精细胞经过一系列复杂和系统的变化,最终成为精子的过程。精子在曲细精管内生成,随睾丸分泌物进入附睾内逐渐成熟;排出的精子进入女性生殖道获能并粘附在输卵管壁上,等待卵细胞经过并与其相遇,精子通过其顶体酶作用穿过透明带,与卵细胞结合并融合完成受精过程。精子发生、成熟、获能与受精,任一环节出现障碍,均会影响男性生育能力。E-cadherin是钙离子依赖性的介导细胞间粘附和信号转导的跨膜糖蛋白,位于精子头部,覆盖于整个顶体赤道板和顶体后区,参与精子发生与精卵融合过程,保证男性的正常生育能力。
Spermatogenesis is a process by which spermatogenic cells undergo a series of complex and systematic changes in the testes that eventually become sperm. Sperm in the seminiferous tubules generated, with the testis secretions into the epididymis gradually mature; excreted sperm into the female reproductive tract was able to adhere and stick to the wall of the fallopian tubes, waiting for egg cells to pass and meet with them, spermatozoa Through the zona pellucida, combined with the egg cells and fusion to complete the fertilization process. Spermatogenesis, maturation, fertility and fertilization, any obstacle in the link, will affect male fertility. E-cadherin is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion and signal transduction. Located in the sperm head, E-cadherin covers the entire acrosomal plateaus and the acrosome region and participates in spermiogenesis and sperm-egg fusion Process, to ensure the normal male fertility.