由多形核白细胞和单核吞噬细胞产生的反应性氧中间产物(ROI),如超氧化物基、过 氧化氢、氢氧根、次氯酸盐和单氧,在针对侵入微生物的非特异性免疫中起主要作用。恶性疟原虫抗原能够活化血液中的吞噬细胞产生ROI,以此杀伤寄生虫和引起溶血等病理学改变。但ROI在决定人类感染疟原虫后的转归中究竟起多大作用尚属未知。经不同化合物如PMA、FMLP、TNF刺激后,吞噬细胞可产生ROI。将化学荧光化合物(如鲁米诺)加入产生ROI的细胞、细胞器或非细胞 Reactive oxygen intermediates (ROIs) produced by polymorphonuclear leukocytes and mononuclear phagocytes, such as superoxide radicals, hydrogen peroxide, hydroxide, hypochlorite, and monooxygen, are nonspecific Immunization plays a major role. Plasmodium falciparum antigen can activate phagocytes in the blood to produce ROI, in order to kill parasites and cause pathological changes such as hemolysis. However, it is unknown how much the ROI will play in determining the outcome of human infection with Plasmodium. After different compounds such as PMA, FMLP, TNF stimulation, phagocytic cells can produce ROI. Chemiluminescent compounds, such as luminol, are added to ROI-producing cells, organelles, or non-cells