论文部分内容阅读
目的探讨他汀类药物联合治疗性生活方式改变(TLC)对社区血脂异常患者的效果评价。方法选择社区内符合他汀类药物治疗的血脂异常患者231例,计算机随机分成2组:干预组112例,给予他汀联合TLC的综合干预;对照组119例,给予他汀治疗及门诊常规的血脂异常知识教育。分别测得2组治疗前、治疗3个月后的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(Glu)水平,统计干预组干预前、后的健康知识问卷成绩。结果干预3个月后,干预组TC、TG、LDL-C、Glu水平均较治疗前降低,差异有统计学意义(P<0.05),对照组患者只有TC、LDL-C水平较治疗前降低,差异有统计学意义(P<0.05),TG、Glu水平较治疗前无明显变化,差异无统计学意义(P>0.05),2组的HDL-C较治疗前均无明显变化,差异无统计学意义(P>0.05);组间比较,治疗3个月后干预组的患者TC、TG、LDL-C和Glu水平低于对照组,差异有统计学意义(P<0.05);干预组的健康知识问卷成绩,干预前后比较,差异有统计学意义(P<0.001)。结论社区综合防治干预对血脂异常患者的效果更好,TLC是血脂异常患者治疗的基础措施。
Objective To investigate the effect of statins combined with therapeutic lifestyle change (TLC) on the patients with community dyslipidemia. Methods A total of 231 patients with dyslipidemia who were treated with statins in the community were enrolled. The patients were randomly divided into two groups: 112 in the intervention group and 110 in the control group. The control group received 119 mg of statin therapy and routine dyslipidemia education. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) Blood Glucose (Glu) levels, statistical intervention group intervention before and after the health knowledge questionnaire scores. Results After intervention for 3 months, the levels of TC, TG, LDL-C and Glu in the intervention group were significantly lower than those before treatment (P <0.05), and only TC and LDL-C in the control group were lower than those before treatment , The difference was statistically significant (P <0.05), TG, Glu levels did not change significantly compared with before treatment, the difference was not statistically significant (P> 0.05), two groups of HDL-C than before treatment had no significant change, no difference The levels of TC, TG, LDL-C and Glu in the intervention group were lower than those in the control group after 3 months of treatment (P <0.05), and the difference was statistically significant Health knowledge questionnaire scores, before and after intervention, the difference was statistically significant (P <0.001). Conclusion Community-based prevention and treatment interventions are more effective in patients with dyslipidemia. TLC is the basic treatment for patients with dyslipidemia.