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抗精子抗体(AsAb),人精浆免疫抑制因子(HSPIF)和针对精子细胞的LPCA反应,都与免疫性不孕的发生有关,HSPIF更与习惯性流产密切相关。不孕夫妇AsAb检出率为24.0％(126/526),流产夫妇阳性率55.6％(16/29),显著高于怀孕夫妇(3.0％,5/66),P<0.01。不孕症的男性或妻子流产的男性,HSPIF含量分别为321±77和317±66u/ml,显著低于生育男性(431±62u/ml),P<0.05;LPCA不育夫妇阳性率为26.7％(24/90),流产夫妇阳性率为25.0％(6/24),均显著高于怀孕夫妇(3.2％,2/62),P<0.01。经中药治疗,单纯AsAb阳性的89例中已有26例(29.2％)怀孕;LPCA与AsAb均阳性的12例已有2例(16.7％)怀孕。结果表明,对精子的体液免疫与细胞免疫反应经治疗后,可使部分患者恢复生育能力。
Anti-sperm antibodies (AsAb), human seminal plasma immunosuppressive factor (HSPIF) and sperm cells LPCA response, are associated with the occurrence of immune infertility, HSPIF and habitual abortion are closely related. AsAb detection rate was 24.0% (126/526) in infertile couples and 55.6% (16/29) in miscarriage couples, which was significantly higher than that of pregnant couples (3.0%, 5/66), P <0.01. The infertility of men or wives abortion of men, HSPIF content were 321 ± 77 and 317 ± 66u / ml, significantly lower than the male (431 ± 62u / ml), P <0.05; LPCA infertility couple positive rate was 26.7 % (24/90). The positive rate of miscarriage was 25.0% (6/24), which was significantly higher than that of pregnant couples (3.2%, 2/62), P <0.01. Twenty-two (29.2%) of 89 AsAb-positive patients were pregnant with traditional Chinese medicine. Two of 12 (16.7%) pregnant women were positive for both LPCA and AsAb. The results show that the sperm humoral immunity and cellular immune response after treatment, some patients can restore fertility.