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本实验动态地检测了油酸所致大鼠肺血管通透性增高的发生、发展过程中肺组织中α、β肾上腺素能受体(αAR、βAR)的最大结合容量及亲和力的变化。结果发现:实验组大鼠肺组织中αAR与βAR之间的平衡遭到了破坏,αAR显著增多,而βAR却显著减少。应用αAR阻断剂——酚妥拉明或βAR激动剂——舒喘灵均可有效地防治油酸引起的大鼠肺血管通透性增高,使肺系数明显减小,支气管肺泡灌洗液中蛋白质含量明显减少,肺组织病变明显减轻。实验结果提示:肾上腺素能受体在肺微血管通透性的调控过程中可能起着重要的作用;肺组织中αAR与βAR之间的平衡失调可能是肺血管通透性增高的重要原因;纠正这种失衡是防治通透性肺水肿的有效手段。
This experiment dynamically detected oleic acid induced pulmonary vascular permeability increased the development of lung tissue in the α, β adrenergic receptors (αAR, βAR) maximum binding capacity and affinity changes. The results showed that the balance between αAR and βAR in the lung tissue of the experimental group was destroyed, αAR increased significantly, and βAR decreased significantly. Application of αAR blockers - phentolamine or βAR agonist - Salbutamol can effectively prevent oleic acid-induced pulmonary vascular permeability increased, the lung coefficient was significantly reduced, bronchoalveolar lavage fluid Significantly reduced protein content, lung tissue lesions significantly reduced. The experimental results suggest that adrenergic receptor may play an important role in the regulation of pulmonary microvascular permeability. The imbalance between αAR and βAR in lung tissue may be an important reason for the increase of pulmonary vascular permeability. This imbalance is an effective means of prevention and treatment of pulmonary edema.