系统性红斑狼疮(SLE)是全身性疾病。进行性侵犯皮肤、关节、肾、中枢神经系统,亦可累及肺和心血管系统。狼疮肾炎是指SLE病程中肾脏受侵犯,临床上有尿常规异常及肾功能异常,肾活检有组织病理和免疫病理上的改变。小儿狼疮肾炎与成人相比发病急、病情重、预后差。早期诊断及时采用肾上腺皮质激素及与细胞毒药物联合治疗,可使病程、并发症及预后得到改善。 Systemic lupus erythematosus (SLE) is a systemic disease. Sexual assault on the skin, joints, kidneys, central nervous system, but also the lungs and cardiovascular system. Lupus nephritis refers to the SLE course of the kidney invasion, clinically abnormal urine and renal dysfunction, renal biopsy histopathology and immunopathological changes. Children with acute onset of lupus nephritis compared with adults, severe illness, poor prognosis. Early diagnosis and timely use of adrenal cortical hormones and cytotoxic drugs combined treatment, the course of disease, complications and prognosis can be improved.