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目的:探讨慢性阻塞性肺病急性加重期(AECOPD)合并急性冠脉综合征(ACS)的危险因素。方法:回顾性分析149例AECOPD患者临床资料。比较合并ACS患者(A组,33例)及单纯AECOPD患者(B组,116例)在一般情况、既往史、基础疾病、临床症状及实验室资料等方面上的差异。结果:A组年龄较大,肺功能状况更差,有冠心病、高血压、糖尿病既往史者更多;胸痛、双下肢水肿伴发率更高;D-二聚体、炎症标志物、心梗四项值、血糖浓度、丙氨酸氨基转移酶及天冬氨酸氨基转移酶、尿素氮及肌酐值较高,以上差异均有统计学意义(P<0.01或P<0.05)。结论:高龄、肺功能差、冠心病等病史、胸痛等伴发症状,以及凝血、炎症、心梗与肝肾功能指标的升高等,是AECOPD合并ACS的危险因素。
Objective: To explore the risk factors of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with acute coronary syndrome (ACS). Methods: A retrospective analysis of 149 cases of AECOPD clinical data. The differences between general patients, past medical history, underlying diseases, clinical symptoms and laboratory data were compared among patients with ACS (group A, n = 33) and patients with simple AECOPD (group B, n = 116). Results: A group was older and had worse pulmonary function, more history of coronary heart disease, hypertension and diabetes, chest pain and higher extremity edema, D-dimer, inflammatory markers, heart The four values of stem, blood glucose, alanine aminotransferase, aspartate aminotransferase, urea nitrogen and creatinine were all higher than those of control group (P <0.01 or P <0.05). Conclusion: AECOPD is a risk factor for AECOPD complicated with ACS in elderly patients with poor pulmonary function, history of coronary heart disease, chest pain and other complications, as well as coagulation, inflammation, myocardial infarction and liver and kidney function.