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目的探讨T细胞非霍奇金淋巴瘤的临床病理特点和免疫表型。方法对77例T细胞非霍奇金淋巴瘤进行苏木素和伊红染色(HE)和免疫组织化学检查,按WHO 2008年《造血和淋巴组织肿瘤的病理学和遗传学》标准进行分类。结果 77例T细胞非霍奇金淋巴瘤中,鼻型结外NK/T细胞淋巴瘤32例(41.6%),非特异性外周T细胞淋巴瘤20例(26.0%),间变性大细胞淋巴瘤11例(14.3%),前驱T淋巴细胞淋巴瘤9例(11.7%)。结论 T细胞非霍奇金淋巴瘤中,最常发生的亚型是鼻型结外NK/T细胞淋巴瘤,其次为非特异性外周T细胞淋巴瘤、间变性大细胞淋巴瘤和前驱T淋巴细胞淋巴瘤。其中,鼻型结外NK/T细胞淋巴瘤预后较差,而间变性大细胞淋巴瘤预后相对较好。
Objective To investigate the clinicopathological characteristics and immunophenotype of T cell non-Hodgkin’s lymphoma. Methods Hematoxylin and eosin (HE) and immunohistochemistry were performed on 77 T-cell non-Hodgkin’s lymphoma and classified according to WHO’s “Pathology and Genetics of Hematopoietic and Lympho Tumor” criteria in 2008. Results Of the 77 T-cell non-Hodgkin’s lymphomas, 32 (41.6%) had nasal type extranodal NK / T cell lymphoma, 20 (26.0%) nonspecific peripheral T cell lymphomas, 11 cases (14.3%), 9 cases of precursor T lymphocytic lymphoma (11.7%). Conclusions The most common subtypes of T-cell non-Hodgkin’s lymphoma are nasal extranodal NK / T cell lymphoma, followed by nonspecific peripheral T-cell lymphoma, anaplastic large cell lymphoma and prodromal T lymphocyte Lymphoma. Among them, the nose type extranodal NK / T cell lymphoma prognosis is poor, and the prognosis of anaplastic large cell lymphoma is relatively good.