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目的探讨海南黎、汉族女性高危型人乳头瘤病毒(High-risk human papillomavirus,HR-HPV)的感染及致病特点。方法以第二代杂交捕获法(Hybrid Capture 2,HC2)检测199例黎族与397例汉族女性宫颈脱落细胞的HR-HPV DNA,对比黎、汉族病毒感染与年龄及宫颈病变的关系。结果(1)总体上HR-HPV感染率(分别26.63%与26.45%)及病毒载量在黎、汉族间无明显差异(均P>0.05);黎族感染率与年龄正相关(P<0.05),载量随年龄增长呈倒“V”字形分布,而汉族样本HR-HPV感染率及病毒载量的年龄变化趋势均与黎族相反。(2)黎、汉族样本HR-HPV感染率在不同宫颈病变中的变化相似,同级别宫颈病变者的病毒载量没有民族差异(均P>0.05)。结论海南黎族HR-HPV感染的年龄变化特点有别于当地汉族,暂未发现病毒的致病性存在民族差异。
Objective To investigate the infection and pathogenic characteristics of high-risk human papillomavirus (HR-HPV) in Hainan and Hainan women. Methods Hybridization 2 (HC2) was used to detect the HR-HPV DNA in 199 cases of cervical exfoliated cells from 397 Han and Han nationality women. The relationship between HPV infection and age and cervical lesions was analyzed. Results (1) There was no significant difference in HR-HPV infection rate (26.63% vs. 26.45%, respectively) and viral load between Lebanon and Han nationality (all P> 0.05) , And the load distribution turned “V” shape with age. However, the age trend of HR-HPV infection rate and viral load of Han sample were opposite to that of Li nationality. (2) The prevalence of HR-HPV infection in Li and Han nationality samples was similar in different cervical lesions. There was no national difference in the viral load among the same-grade cervical lesions (all P> 0.05). Conclusion The age-specific characteristics of HR-HPV infection in Hainan Li ethnic group are different from those of the Han nationality in China. However, no ethnic differences have been found in the pathogenicity of the virus.