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阿洛西林钠属于具有广谱抗菌效能的半合成青霉素族,在医院中主要用于非肠道给药,以往报道的阿洛西林钠HPLC 测定法,未能使阿洛西林钠与其降解产物分离,本文介绍了能用作稳定性研究的HPLC 法,并用TLC 法进行了核对。
Azlocillin sodium is a semi-synthetic penicillin family with broad-spectrum antimicrobial efficacy. It is mainly used in hospitals for parenteral administration. The previously reported azlocillin sodium HPLC assay failed to separate azlocillin sodium from its degradation products , This article describes the HPLC method that can be used as a stability study and is checked by the TLC method.