为观察香菇多糖脂质体（ＬｉｐｏｓｏｍｅｓｃｏｎｔａｉｎｉｎｇＬｅｎｔｉｎａｎ，ＬｉｐＬＮＴ）与低剂量ＩＬ２协同体内扩增，激活腹腔巨噬细胞（Ｐｅｒｉｔｏｎｅａｌｍａｃｒｏｐｈａｇｅ，ＰＭ）杀瘤活性。体内诱导Ｂａｌｂ／ｃ小鼠２ｄ后，收集计数腹腔渗出细胞（Ｐｅｒｉｔｏｎｅａｌｅｘｕｄａｔｅｃｅｌｓ，ＰＥＣ）及ＰＭ，监测ＰＭ细胞毒及ＴＮＦ活性，并于香菇多糖（Ｌｅｎｔｉａｎ，ＬＮＴ）进行了比较。结果：ＬｉｐＬＮＴ，ＬＮＴ与ＩＬ２联合可协同使ＰＥＣ体内大量扩增，ＰＭ细胞毒活性及ＴＮＦ分泌显著增加，其中ＬｉｐＬＮＴ较ＬＮＴ最小有效剂量减小５倍，最适剂量减少４倍，而ＰＭ杀瘤活性提高３０％，且以靶向扩增ＰＭ为主，达７２％。结论：ＬｉｐＬＮＴ较ＬＮＴ生物活性显著提高，ＬｉｐＬＮＴ与小剂量ＩＬ２联合使ＰＭ、ＰＥＣ体内大量增殖，ＰＭ杀瘤活性增强并促进ＴＮＦ生成。 In order to observe the synergistic in vivo expansion of LiposomescontainingLentinan (LipLNT) and lowdose IL2, activation of peritoneal macrophage (PM) was performed. Balb / c mice were induced in vivo for 2 days. Peritonealexudatecels (PEC) and PM ¢ ñ were collected and counted for cytotoxicity and TNF activity in PM ¢ ñ cells. Lenti, LNT were compared. Results: LipLNT, LNT and IL2 combined can make a large number of PEC in vivo expansion, PM  cytotoxic activity and TNF secretion increased significantly, which LipLNT LNT minimum effective dose was reduced 5 times, the optimum dose decreased 4 times, while the PM  tumor killing activity increased by 30%, and target-based amplification of PM , 72%. CONCLUSION: LipLNT has significantly higher biological activity than LNT. Combined with LipLNT and lowdose IL2, PM  and PEC proliferate in large quantities, and PM  tumor killing activity is enhanced and TNF production is promoted.