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目的:探讨透明质酸钠在膀胱灌注治疗中对感觉敏感型OAB患者膀胱功能影响的有效性和安全性。方法:针对40例感觉敏感型OAB患者行透明质酸钠膀胱灌注治疗,每周1次,连续灌注4周。每月1次,6个月后观察效果,记录患者治疗前后间质性膀胱炎症状评分(ICSI)、最大膀胱容量,比较治疗前后指标变化。结果:患者病症得到了有效的控制,其中9例灌注2次后出血停止;11例患者灌注4次后,症状明显减轻;有12例患者灌注8次后,同时给予止血、抗感染、支持治疗后,病情开始好转;有7例患者在治疗前后均作检查,采取针对性灌注方法,在后期能控制;有1例由于膀胱、盆腔广泛转移导致死亡。结论:透明质酸钠对感觉敏感型OAB患者膀胱功能影响的治疗,安全有效,有针对性。
Objective: To investigate the efficacy and safety of sodium hyaluronate on bladder function in patients with sensory-sensitive OAB during bladder irrigation. Methods: Forty patients with sensory-responsive OAB were treated with intravesical instillation of sodium hyaluronate once a week for 4 weeks. One month and six months later, the effect was recorded. ICSI and maximum bladder volume before and after treatment were recorded. The changes of indexes before and after treatment were compared. Results: The patient’s condition was effectively controlled. Nine patients stopped bleeding after perfusion twice. Eleven patients were relieved after four times of perfusion. Symptoms were relieved after 12 patients were infused for 8 times. Meanwhile, hemostasis, anti-infection and supportive care were given After the disease began to improve; 7 patients were examined before and after treatment, to take targeted perfusion method, can be controlled in the late; one case due to extensive bladder and pelvic metastasis leading to death. Conclusion: The treatment of sodium hyaluronate on bladder function in patients with sensory-sensitive OAB is safe, effective and targeted.