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为探讨喉癌组织基膜和树突状细胞（DC）的临床意义，采用免疫组织化学方法以抗层粘连蛋白、抗Ⅳ胶原、抗S－100蛋白抗体，标记68例喉癌患者癌组织与21例非喉癌组织基膜和DC。结果表明：68例喉癌者基膜呈非连续线状为39例（573％），21例非喉癌者呈连续线状为18例（85．7％）；喉癌者中DC检出率为63．2％（43／68），非喉癌者中很少见到DC（2／21）。基膜的连续性、DC的检出率与病理分级、临床分期有明显相关性（P＜0．05），病理分级越低，临床分期越高，基膜断裂者越多，DC检出率越低。基膜完整的喉癌患者术后5年生存率明显高于基膜断裂者，DC阳性的喉癌患者术后5年生存率也明显高于阴性者；基膜完整且DC阳性的喉癌患者术后5年生存率最高。表明基膜和DC的检测对判断喉癌患者的预后有一定参考价值。
To investigate the clinical significance of laryngeal carcinoma basement membrane and dendritic cells (DCs), immunohistochemistry was used to detect the expression of laminin, anti-Ⅳ collagen and anti-S-100 protein in 68 patients with laryngeal carcinoma Twenty-one non-laryngeal cancer tissues and DCs. The results showed that in 68 laryngeal cancer patients, the basement membrane was discontinuous in 39 cases (573%) and in 21 cases non-laryngeal cancer in 18 cases (85.7% The rate was 63.2% (43/68), rare in non-laryngeal cancer seen in DC (2/21). The continuity of basement membrane, the detection rate of DC were significantly correlated with the pathological grade and clinical stage (P <0.05). The lower the pathological grade, the higher the clinical stage, the more basement membrane rupture, the detection rate of DC Lower. The 5-year survival rate of patients with laryngeal carcinoma with complete basement membrane was significantly higher than that with basement membrane rupture. The 5-year survival rate of patients with laryngeal carcinoma with positive DC was also significantly higher than those with negative basement membrane. Five years after surgery the highest survival rate. That the basement membrane and DC detection of the prognosis of laryngeal cancer patients have some reference value.