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以无水三氯化铝(AlCl3)为催化剂,对氯苯甲酰氯和苯甲醚为起始原料,经过Friedel-Crafts酰基化反应、去甲基反应、水解反应等过程合成了4-羟基-4’-氯二苯甲酮。考察了催化剂用量、苯甲醚用量、反应温度、反应时间等对产率的影响,得到了较适宜的工艺条件为对氯苯甲酰氯30 g,苯甲醚18 g,三氯化铝33 g,溶剂氯苯80 g,反应温度130℃,回流时间1.5 h,产率97.1%。改进后的方法能节约试剂,节省时间,减少污染。
Ammonia trichloride (AlCl3) as catalyst, chlorobenzoyl chloride and anisole as starting materials, after Friedel-Crafts acylation, demethylation, hydrolysis and other processes synthesized 4-hydroxy- 4’-chlorobenzophenone. The effects of the amount of catalyst, the amount of anisole, the reaction temperature and the reaction time on the yield were investigated. The suitable process conditions were as follows: 30 g of p-chlorobenzoyl chloride, 18 g of anisole and 33 g of aluminum trichloride , Solvent chlorobenzene 80 g, reaction temperature 130 ℃, reflux time 1.5 h, the yield of 97.1%. The improved method can save reagents, save time and reduce pollution.