目的:分析汞中毒性肾病综合征的临床特征，寻找发病的相关危险因素。方法:选取2017年1月至2020年1月北京朝阳医院收治的汞中毒患者126例为研究对象，收集患者年龄、性别、汞接触史等一般资料及尿汞、尿肌酐等实验室资料，统计其中发生汞中毒性肾病综合征患者的临床表现及病理分型，采用单因素和多因素logistic回归分析方法对汞中毒性肾病综合征发病的相关危险因素进行分析。结果:汞中毒性肾病综合征患者24例，其中经呼吸道中毒1例，经消化道中毒6例，经皮肤吸收中毒17例；患者除均有肾脏损伤表现外，部分还出现头晕、乏力、手颤、肢体疼痛等类神经症；病理类型主要为膜性肾病（9例）和微小病变型肾病（10例）；多因素logistic回归分析结果显示，汞的消化道和皮肤吸收途径为汞中毒性肾病综合征的危险因素（n OR=21.099、23.840，n P<0.05）。n 结论:汞的吸收途径对汞中毒性肾病综合征发病有重要影响，尤其是皮肤和消化道吸收的汞中毒患者并发肾病综合征的风险较高。“,”Objective:To analyse the clinical characteristics of mercury-toxic nephrotic syndrome and to find the risk factors.Methods:A total of 126 patients with mercury-toxic admitted to Beijing Chaoyang Hospital from January 2017 to January 2020 were selected as the research objectives. General data such as age, gender, mercury exposure history of all patients and laboratory data such as urine mercury and urine creatinine were collected. The clinical manifestations and pathological types of patients with mercury-toxic nephrotic syndrome were analyzed, and the risk factors of mercury-toxic nephrotic syndrome were found by univariate and multivariate logistic regression analysis.Results:Among the 24 patients with mercury-toxic nephrotic syndrome, 1 was poisoned by respiratory tract, 6 were poisoned by digestive tract, and 17 were poisoned by skin absorption. In addition to the manifestations of kidney injury, some of the patients also showed neurological symptoms such as dizziness, fatigue, hand tremor, and limb pain. The main pathological types were membranous nephropathy (9 cases) and micropathological nephropathy (10 cases) . The results of multivariate logistic regression analysis showed that the digestive tract and skin absorption pathways of mercury were risk factors for mercury-toxic nephrotic syndrome (n OR=21.099, 23.840, n P<0.05) .n Conclusion:The absorption pathway of mercury has an important influence on the pathogenesis of mercury-toxic nephrotic syndrome, especially in patients with mercury poisoning absorbed by the skin and digestive tract, the risk of complicating nephrotic syndrome is higher.