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作者以标准形态学和细胞化学(过氧化酶、PAS和非特异性脂酶)分析了100例成人急性白血病,其中粒细胞型(AML)74例,18例有奥氏小体。淋巴细胞型(ALL)14例,7例PAS阳性。12例不能分型的急性白血病(AUL)。根据有无奥氏小体和原始细胞过氧化酶的阳性率将AML分为四个亚群,即:(1)无奥氏小体50%过氧化酶为阳性,(2)有奥氏小体50%过氧化酶为阳性,(3)有或无奥氏小体10～50%过氧化酶阳性,(4)无奥氏小体过氧化酶阳性少于10%的四亚群。并观察了各型白血病及其亚群的存活情况。结果:ALL型比其它两型白血病存活期明显长,(P≤0.003)。ALL病人原始细胞PAS阳性例和阴性例之间的存活差异很小,说明PAS反应对ALL病人预后无意义。AML存活中数为46.5周。AUL型为23.8周,AUL型要短些,但无明显统计学意义(P=0.2)。在AML型的几个亚群间,以奥氏小体的有无观察了它们的存活情况。有奥氏小体的存活中数为49.7周,无奥氏小体的为45.4周,无明显统计学差异。原始细胞过氧化酶为10～50%的亚群存活期最长为68周,过氧化酶少于10%的亚群为57周,过氧化酶高于
The authors analyzed 100 cases of adult acute leukemia by standard morphology and cytochemistry (peroxidase, PAS, and non-specific lipase), of which 74 cases were granulocytic (AML) and 18 cases were austenitic. There were 14 cases of lymphocyte type (ALL) and 7 cases of PAS positive. Twelve cases of undifferentiated acute leukemia (AUL). AML was divided into four subgroups according to the presence or absence of aosmophile and the positive rate of the original cell peroxidase, namely: (1) 50% peroxidase-positive without austenitic corpuscle, (2) small aussie The body was 50% peroxidase positive, (3) with or without aosibody 10 to 50% peroxidase positive, (4) no sub-group with aosmophilic peroxidase less than 10%. And observed the survival of various types of leukemia and its subpopulations. RESULTS: The ALL type survived significantly longer than the other two types of leukemia (P≤0.003). The difference in survival between PAS-positive and negative cases of ALL patients in the primary cell is very small, indicating that the PAS response has no significance in the prognosis of ALL patients. The number of AML survivors was 46.5 weeks. The AUL type was 23.8 weeks, and the AUL type was shorter, but there was no significant statistical significance (P=0.2). Among several subgroups of the AML type, their survival was observed with the presence of austenitic corpuscles. There were 49.7 weeks of survival for auris bodies and 45.4 weeks for no austenitic bodies, with no significant difference. Subpopulations with 10 to 50% of protocell peroxidase survived for a maximum of 68 weeks, subpopulations with less than 10% of peroxidase had 57 weeks, and peroxidase activity was higher than