二尖瓣狭窄是青年妇女的主要心血管疾病之一,虽有研究证实妊娠期间肺动脉压力增加,但妊娠期间跨二尖瓣压力阶差的系列变化尚未见报导,本文报告2例妇女从妊娠早期开始跨二尖瓣压力阶差进行性增加。例1,34岁黑人妇女,孕3产2,有二尖瓣狭窄病史.初诊时妊娠8周,无端坐呼吸、活动性呼吸困难及胸痛.体检时唯一阳性体征是心尖部2/6级舒张期隆隆样杂音,左侧位超声心动图显示左房扩大,二尖瓣狭窄。Doppler超声心动图显示二尖瓣最大流速1.4m/s,压差减半时间170ms,二尖瓣面积1.45cm~2,在妊娠第7和第9个月重复了超 Mitral stenosis is one of the major cardiovascular diseases in young women. Although studies have shown that pulmonary artery pressure increases during pregnancy, a series of changes across the mitral pressure gradient during pregnancy have not been reported. In this paper, 2 women were reported from the first trimester of pregnancy The progressive increase in pressure gradient across the mitral valve begins. Example 1, 34-year-old black woman, pregnant 3 3, had a history of mitral stenosis .When the first visit of pregnancy 8 weeks, no sitting breathing, active dyspnea and chest pain. The only positive physical examination was apical 2/6 level Period rumbling noise, left echocardiography showed left atrial enlargement, mitral stenosis. Doppler echocardiography showed mitral maximum flow rate of 1.4m / s, pressure half-time 170ms, mitral area 1.45cm ~ 2, in the seventh and ninth months of pregnancy repeated super