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分别经尾静脉给对照、妊娠17天和泌乳(分娩后1天)的BALB/c小鼠注射1.85×10~4Bq/g体重~(147)Pm(NO_3)_3溶液,于注射后不同时间活杀母鼠及子鼠,以便确定当时~(147)Pm的滞留和分布。实验结果表明,3组动物体内~(147)Pm的存留有显著差异。尽管3组动物肝脏初始摄取~(147)Pm的量均约为注射量的60％,但两实验组动物肝脏~(147)Pm生物半排期显著长于对照组。注射后1,14和21天,股骨中~(147)Pm活度亦显著高于对照组(P<0.05)。泌乳组仔鼠体内~(147)Pm含量在注射后1和4天比妊娠组仔鼠高20多倍。妊娠晚期母鼠胎盘及胎膜~(147)Pm含量明显高于胎鼠,提示,胎盘屏障限制了~(147)Pm向仔代的转移。
The BALB / c mice injected with 1.85 × 10 ~ 4Bq / g body weight ~ (147) Pm (NO_3) _3 solution via the caudal vein, 17 days after gestation, and lactation (1 day after delivery) Dams and rats were sacrificed to determine the retention and distribution of ~ (147) Pm at that time. The experimental results show that there is a significant difference in the survival of ~ (147) Pm in three groups of animals. Although the initial intake of ~ (147) Pm in the liver of three groups of animals was about 60% of the injected dose, the biological half-life of ~ 147 Pm in the liver of the two experimental groups was significantly longer than that of the control group. At 1, 14 and 21 days after injection, the activity of ~ (147) Pm in the femur was also significantly higher than that in the control group (P <0.05). The level of ~ (147) Pm in the lactation group was 20 times higher than that in the gestation group at 1 and 4 days after injection. The levels of ~ (147) Pm in placenta and fetal membranes in the third trimester were significantly higher than those in the fetal rats, suggesting that the placental barrier limits the transfer of ~ (147) Pm to the progeny.