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目的探讨一种新型口服的血管紧张素转换酶抑制剂赖诺普利与地高辛治疗老年顽固性心衰的疗效。方法选择住院患者进行NYHA心功能分级为Ⅲ级,Ⅳ级,常规治疗2周无效且已经确诊为老年顽固性充血性心力衰竭病例258例,改用赖诺普利与小剂量地高辛口服;治疗后心功能改善2级为有效,改善1级为有效,无变化或者恶化者为无效。结果 258例患者中,心功能Ⅲ级者123例,有效率为78.86%;心功能Ⅳ级者135例,有效率为77.78%;总有效率为78.29%。结论赖诺普利联合小剂量地高辛治疗充血性心力衰竭具有疗效较好,服药方便,用药依从性好,比较经济的优点,可在临床上应用。
Objective To investigate the efficacy of a new oral administration of angiotensin-converting enzyme inhibitor lisinopril and digoxin in the treatment of elderly refractory heart failure. Methods Inpatients NYHA functional class Ⅲ, Ⅳ, routine treatment of 2 weeks invalid and has been diagnosed 258 cases of elderly patients with refractory congestive heart failure, switch to lisinopril and low-dose digoxin orally; After treatment, improvement of heart function was effective at grade 2, and improvement of grade 1 was effective. No change or deterioration was found. Results Among the 258 patients, 123 patients with grade Ⅲ cardiac function had an effective rate of 78.86%. 135 patients with grade Ⅳ cardiac function had an effective rate of 77.78% and a total effective rate of 78.29%. Conclusion Lisinopril combined with low-dose digoxin for congestive heart failure has better curative effect, convenient administration, good medication compliance and more economical advantages, which can be used clinically.