目的:考察黄麦合剂中淫羊藿苷、二苯乙烯苷、金丝桃苷的稳定性。方法:以黄芪甲苷、巴戟天药材的TLC鉴别试验,以及淫羊藿苷、二苯乙烯苷、金丝桃苷的HPLC色谱法含量测定为指标,考察黄麦合剂在加速试验及长期试验条件下的稳定性。结果:在加速试验及长期试验条件下,黄芪甲苷、巴戟天药材以及淫羊藿苷具有良好的稳定性;二苯乙烯苷、金丝桃苷在加速试验、长期试验条件下稳定性差。结论:黄麦合剂各成分中二苯乙烯苷、金丝桃苷稳定性不佳,应尝试改造成固体剂型,以保证稳定性。 Objective: To investigate the stability of icariin, stilbene glycoside and hyperoside in Huangma mixture. Methods: TLC identification test of Astragaloside and Morinda officinalis, and HPLC chromatographic determination of icariin, stilbene glycoside and hyperoside were used as indexes to investigate the effects of flavonoids in accelerated test and long-term test Under the conditions of stability. Results: Astragaloside, Morinda officinalis and Icariin had good stability under accelerated test and long-term test. Stilbene and hyperoside showed poor stability under accelerated test and long-term test. Conclusion: The stability of stilbene glycoside and hyperoside in the components of flavonoids mixture is not good, and the solid dosage form should be modified to ensure the stability.