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目的探讨结直肠间质瘤的临床诊断、治疗和预后。方法回顾性分析20例结直肠间质瘤患者的临床资料并加以随访。结果临床表现为消化道出血10例、腹部不适5例、腹部肿块3例,体检发现直肠肿物2例。直肠15例,结肠5例。20例均行手术治疗,诊断为良性2例,交界性1例,恶性17例。免疫组化CD117(+)95%(19/20),CD34(+)80%(16/20)。随访率80%,患者中位生存时间为54个月。结论胃肠道间质瘤(GIST)的最后诊断需依靠病理,结直肠间质瘤仍以外科治疗为主,原则上应行局部完全切除。
Objective To investigate the clinical diagnosis, treatment and prognosis of colorectal stromal tumors. Methods The clinical data of 20 patients with colorectal stromal tumors were retrospectively analyzed and followed up. Results The clinical manifestations of gastrointestinal bleeding in 10 cases, abdominal discomfort in 5 cases, 3 cases of abdominal mass, physical examination found rectal mass in 2 cases. 15 cases of rectum, 5 cases of colon. Twenty patients underwent surgical treatment. The diagnosis was benign in 2 cases, borderline in 1 case and malignant in 17 cases. Immunohistochemical CD117 (+) 95% (19/20), CD34 (+) 80% (16/20). The follow-up rate was 80% and the median survival time was 54 months. Conclusions The final diagnosis of gastrointestinal stromal tumor (GIST) depends on the pathology. The primary treatment of colorectal stromal tumors is still surgical treatment. In principle, partial resection should be performed locally.