研究表明,在霍乱流行区,口服霍乱B亚单位全菌体菌苗(B-WC)能诱导志愿者产生肠道免疫记忆应答,并且这种免疫记忆可因在流行区接触低剂量霍乱弧菌抗原(包括霍乱毒素或交叉反应性不耐热肠毒素)而得以维持.本文旨在研究2或3次B-WC免疫能否在非霍乱流行区同样有效地诱导抗霍乱毒素和抗细菌抗原的免疫记忆 Studies have shown that oral administration of cholera B subunit whole bacterial vaccine (B-WC) in cholera-endemic areas can induce volunteers to produce intestinal immune memory response, and this immune memory may be due to endemic areas exposed to low doses of V. cholerae Antigens (including cholera toxin or cross-reactive heat-labile enterotoxin) .This paper aims to investigate whether 2 or 3 immunizations with B-WC could equally effectively induce anti-cholera toxin and antibacterial antigens in non-cholera-endemic areas Immune memory