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我们用RIA法对55例肝癌进行了血清学T_3、T_4rT3测定,发现T_3、T_4、rT3代谢变化与肝癌病情息息相关,对肝癌患者治疗起到积极的指导作用。 对象和方法 一、对象: (一)肝癌组:55例肝癌(男47,女8)年龄29～65岁,均经病理、B超、CT、AFP等检查证实,按肿瘤内科手册分Ⅲ期;Ⅰ期,无明显肝癌症状体征者;Ⅱ期,超过Ⅰ期标准而无Ⅲ期证据者;Ⅲ期,有明显恶病质、黄疸、腹水或肝外转移之一者。 (二)对照组:30例(男20,女10)年龄27～58岁,均为我院健康查体者,无肝病、甲状腺病等。 二、方法: (一)T_3、T_4、rT3试剂盒山40l所提供,按说明书操作。 (二)仪器为西安262厂产FJ—2008 P全自动γ计数仪。 结果 肝癌组与正常对照组血清T_3、T_4、rT3结果如表1。Ⅱ、Ⅲ期肝癌T_3明显低于正常对照组(p<0.05),Ⅲ期肝癌rT3明显高于对照组(p<0.05),各期肝癌T_4略有变化,但无统计学意义(p>0.05)。
We used RIA method to detect serum T_3 and T_4rT3 in 55 cases of hepatocellular carcinoma. We found that the metabolic changes of T_3, T_4, and rT3 are closely related to the condition of liver cancer and play a positive role in the treatment of liver cancer patients. Subjects and Methods I. Object: (1) Liver cancer group: 55 cases of liver cancer (male 47, female 8) aged 29 to 65 years were confirmed by pathology, B-ultrasonography, CT, AFP, etc., according to the Handbook of Oncology Stage I, no significant liver cancer symptoms and signs; Phase II, more than the standard of phase I and no evidence of phase III; phase III, there is obvious cachexia, jaundice, ascites, or extrahepatic metastasis. (B) the control group: 30 cases (male 20, female 10) age of 27 to 58 years old, are all physical examination in our hospital, no liver disease, thyroid disease. Second, the method: (A) T_3, T_4, rT3 kit provided by 40l, according to the instructions. (b) The instrument is a FJ-2008 P automatic gamma counter produced by Xi’an 262 Factory. Results The results of serum T3, T4, and rT3 in the liver cancer group and the normal control group are shown in Table 1. The T_3 of stage II and III hepatocellular carcinoma was significantly lower than that of the normal control group (p<0.05), and the level of stage III hepatic carcinoma was significantly higher than that of the control group (p<0.05). The T_4 of hepatocellular carcinoma in each stage slightly changed, but there was no statistical significance (p>0.05). ).