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目的:研究200列肺癌手术病例标本中CK17及CK18表达与肺癌生物学行为的关系。方法:用免疫组化S—P法检测200例肺癌手术标本中CK17、CK18的表达。结果:肺高分化及中分化鳞癌(CK17)及腺癌(CK18)阳性表达为100％;肺低分化鳞癌CK17表达及肺低分化腺癌CK18表达平均大于50％;而肺未分化癌中CK17或CK18表达率均小于20％;CK17、CK18表达与肺癌瘤大小及发病年龄无关;CK17、CK18的阳性表达与肺癌组织学分化程度有关P<0.05;此外CK17、CK18的表达与肺门淋巴结转移呈负相关P<0.05。结论:CK17、CK18的表达与肺癌生物学行为有关,并且通过肺癌组织中角蛋白CK17及CK18能正确区分肺低分化鳞癌及肺癌,对于肿瘤内科有重要指导意义。
Objective: To investigate the relationship between the expression of CK17 and CK18 in 200 specimens of lung cancer and the biological behavior of lung cancer. Methods: The immunohistochemical S-P method was used to detect the expression of CK17 and CK18 in 200 lung cancer specimens. Results: The positive expression rates of CK17 and CK18 in lung tissues were 100%. CK17 expression in poorly differentiated lung squamous cell carcinoma and CK18 in poorly differentiated adenocarcinoma of the lung were more than 50% on average. In undifferentiated lung cancer, CK17 or CK18 expression rates were less than 20%; CK17, CK18 expression and lung cancer size and age of onset has nothing to do; CK17, CK18 positive expression and lung cancer histological differentiation of P <0.05; in addition CK17, CK18 expression and hilar Lymph node metastasis was negatively correlated P <0.05. Conclusion: The expression of CK17 and CK18 are related to the biological behavior of lung cancer. And the correct differentiation of squamous cell carcinoma from lung cancer and lung cancer by CK17 and CK18 in lung cancer is of great guiding significance for oncology.